Magnetic Polymer Colloids and Combinatorial Thin Films for Theranostic Applications

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs), due to their controllable sizes, relatively long in vivo half-life , shape and limited aggregation are best for theranostic applications such as MRI contrast enhancement agents, as contrast enhancement agents, hyperthermia cancer treatment, and delivery of drug. It is important to protect the magnetic particles with a biocompatible and biodegradable polymer or with other coatings to reduce the risk of particle aggregation and prevents the magnetic particle from being exposed directly to the body. Although research about magnetic nanoparticles have been developed for many years, there is still more work that is needed to be done that can be used to stabilize and functionalized these use them for applications such as imaging, hyperthermia, and drug delivery. With the advancement in surface engineering for the development novel systems based on combinatorial films of magnetic colloids provide a beneficial platform therapeutic applications in health care that permits a quick surface-based diagnosis therapeutic applications in health care. This research reports the synthesis and stabilization of magnetic polymer colloids thin film and development of combinatorial thin film to develop a point of care lab on a chip that can be used as a substrate for theranostic applications. This work is dedicated to develop highly stable magnetic colloidal particles with polymers and to create highly disperse particles in solution via emulsion evaporation technique. The co-precipitation method was designated because it‟s simple and most effective chemical method to obtain magnetic nanoparticles. Different types of magnetic colloids were synthesized size, morphology, charge, composition, and magnetic properties. Two different types of magnetic colloids were synthesized and characterized for size, morphology, charge, composition, and magnetic properties. The research work described here is novel and elaborate the encapsulation of magnetite along with doxorubicin using Eudragit E100 polymer shell. The synthesis of highly stabilized emulsion involving the combination of Doxorubicin active anticancer drug molecules in cationic Eudragit E100 with Tween 80 nonionic hydrophilic surfactant is significant from combination of Doxorubicin . The magnetic nanoparticle formulation strategy provides a new and likely scalable route to hydrophilic surfactant is significant from several perspectives. The magnetic iv nanoparticle formulation strategy provides a new and likely scalable route to encapsulate hydrophilic drugs efficiently without involvement design complicated carrier polymer design as well as potential applications magnetic hyperthermia. Several methods have been for the fabrication of combinatorial thin films. Electrostatic self-assembly layer-by-layer is simple, economical, and environmentally friendly procedure to create thin films of desired components centered on electrostatic attractions between substituents charged oppositely and can be used for deposition of uniform multilayers on a diverse range of substrates. In this project, we demonstrate the production of combinatorial film gradients having distinct regions using the LBL technique using prepared magnetic polymer colloids and oppositely charged polyelectrolytes that are stimuli-responsive. These films were described charged polyelectrolytes that are stimuli-responsive. These films were described by using optical microscopy using prepared magnetic polymer colloids and scanning electron miscopy for their surface coverage, morphology, and roughness using prepared magnetic polymer colloids and oppositely charged polyelectrolytes. Surface wettability and hydrophilic nature of the developed films were also determined which are important for diagnostic applications. pH effect has also studied the variation in multilayer thin films consisting of polymer colloids and polyelectrolytes by changing the pH of solutions. The prepared magnetic polymer colloids were also investigated for theranostic applications that include imaging via MRI, in-vitro drug release, and hyperthermia. The magnetically engineered films with a growth in the bilayers number, have been also evaluated in surface-based MR imaging and showing a reducing tendency of intensity magnetically engineered films with a growth in the bilayers number, have been also evaluated in surface-based MR imaging with a growth in the bilayers number, thus could serve as a platform for ultrasensitive imaging for in vitro diagnosis of biological samples as dipstick like approach. These developed magnetic novel and present significant potential for the future efficient simultaneous diagnostic and therapeutic applications.