Abstract:
In this research study, a highly selective and sensitive electrochemical sensor was
designed by coating the glassy carbon electrode (GCE) with the novel PANI/MOF199/Ag nanocomposite for the non-enzymatic electrochemical detection of dopamine
(DA). PANI/MOF-199/Ag nanocomposite was prepared by the in-situ chemical
oxidative polymerization of aniline monomer in the presence of MOF-199 followed
by the deposition of Ag nanoparticles using an in-situ chemical reduction route.
Characterization techniques such as Scanning electron microscopy (SEM), X-ray
powder diffraction (XRD), Fourier transform infra-red (FTIR), and Raman analyses
were used to find out the successful synthesis of the prepared samples. Meanwhile, the
electrochemical performance was investigated by chronoamperometry (CA) and
cyclic voltammetry (CV) not only at different molar concentrations of DA but also
with various compositions of Ag nanoparticles loaded. The PANI/MOF-199/Ag-3%
modified electrode exhibited good electro-catalytic activity with a low detection limit
(LOD) of 0.22µM (S/N = 3), and high sensitivity of 1.421 µAµM-1cm-2
towards DA.
Moreover, in the presence of common interfering biological compounds such as uric
acid (UA), glucose (Glu), and ascorbic acid (AA), the fabricated electrochemical
sensor was found selective to DA detection.
