Systematic evaluation of natural compounds of Colchicum Luteum and Trachyspermum Ammi to identify the potential targets for Rheumatoid Arthritis

Abstract

Rheumatoid Arthritis is a chronic inflammatory disease effecting 0.5 – 1% of the population. Rheumatoid is more common among females as compared to males. It is a progressive disease and there is no cure yet. The current treatment of Rheumatoid Arthritis includes the use commercial drugs that are majorly classified as NSAIDs, DMARDs, Glucocorticoids and Biologics. Trachyspermum Ammi and Colchicum Luteum are the medicinal plants exhibiting anti-inflammatory and anti-oxidant activity. The active phytochemicals of these plants can be used for the inhibition of various inflammatory pathways to slow down the progression of disease without causing any serious side effects as compared to the synthetic commercial drugs. The shortlisted phytochemicals of both the plants showed excellent physical and chemical characteristics to be used as anti-arthritic agent. The comparative in-silico docking analysis of shortlisted phytochemicals and commercial drugs to the common Rheumatoid Arthritis targets showed that various phytochemicals binding affinity was better than the commercial drugs resulting a good target ligand interaction. This analysis concludes that the shortlisted active phytochemicals having better affinity values could be considered for further studies as compared to the commercial drugs available for Rheumatoid Arthritis.