Abstract:
Bacterial Vaginosis (BV) is one of the most frequently reported diseases in
females. The poly microbial infection occurs as a result of an imbalance in the
healthy vaginal microbiome. Worldwide, the bacterial vaginosis prevails in about
21.2 million (29.2%) and the range lies within 8% to 75% in case of third world
countries. Though the disease is not fatal, it may lead to serious health
complications. BV facilitates the onset of sexually transmitted diseases (STDs)
and also plays a crucial role in the delayed prognosis of cervical cancer.
Currently, the ailment is being treated worldwide by the use of antibiotics,
Metronidazole being the most commonly used among them. However, with the
growing concern of antibiotics resistance, the quest for alternative treatment
options continues.
The present study therefore investigates bacteriophages against BV as an
alternative therapeutic option to antibiotics. Bacteriophages are not only safer to
use but also address the issue of resistance. Bacterial resistance reported against
bacteriophages is very less as compared to antibiotics.
The study comprises of the isolation of different bacterial isolates from the BV
positive female patients of the twin cities. 50 samples were collected in
collaboration with Kahota Research Laboratories (KRL), Islamabad. HVS swabs
of the patients were taken and were quadrant streaked on different media for the
isolation of BV causing bacteria.
