Genetic Analysis of Angiotensin Converting Enzyme Ii Gene (Ace Ii) Association Polymorphism in Type 2 Diabetes Mellitus

Abstract

Type 2 Diabetes Mellitus is a metabolic dysfunction that target many organs thus creating complications and linking to increased cardiovascular diseases. This disorder is progressing day by day worldwide. Currently, many studies have supported the involvement of Angiotensin Converting Enzyme II Gene (ACE II) in diabetes, which is a major compound in Rennin-Angiotensin System (RAS) involved in the activation of majority pathophysiological impacts of RAS. This study was designed to screen and study the ACE II gene in the blood samples type 2 diabetic patients and normal healthy individuals in order to investigate the specific genotypes in the diseased and healthy individuals by observing association polymorphism of ACE II gene as three different polymorphs; Insertion (II), insertion-deletion (I/D) and deletion (DD). The results showed more involvement of D allele in both cases in which more DD genotype was analyzed to be present in healthy individuals whereas type 2 diabetic patients possessed I/D genotype more than the other two. This data analysis could lead to the formation of ACE II inhibitors to avoid the progression of Type 2 Diabetes Mellitus