Evaluation of Antidiabetic Potential of Whole Camel Milk and Camel Whey Protein in Streptozotocin Induced Diabetic Rats

Abstract

Diabetes mellitus (DM) is a set of chronic illness characterized by high blood glucose level and misfunctioning of pancreatic β-cells. Insulin is a protein hormone used as pharmacological strategy for the treatment of T2DM, but regular use of insulin makes the body resistant to the defined dose, and it has to be increased with time. It has been used intraperitoneal and subcutaneously by many years to reduce blood glucose level. Camel milk (CM) and its product, camel whey protein (CWP), has been thought to have antidiabetic property. In this study, camel milk and camel whey protein has been used for the treatment of type 2 diabetes. SEM and FTIR were performed for the characterization of camel whey protein. In in-vivo analysis, streptozotocin was induced in normal wister albino rats. On induction, they showed a hyperglycemic effect with P<0.0001 for all groups. To analyze the effect of camel milk and camel whey protein, the lipid profile, liver, and kidney function tests were performed that showed significant effect on diabetes. the treatments showed the significant reduction in the blood glucose, ALT, ALP, creatinine, uric acid, TCHO, TG, LDLC and MDA levels with all P-values of <0.0001 except uric acid with P-value 0.0008. Similarly, increase in albumin, HDLC, SOD and CAT was observed with P-value <0.0001 (except for albumin, CM=0.0044, CWP=<0.0004). Also, the histopathological analysis of the renal and hepatic tissue showed the revert effect by using CM and CWP. The results of current study show that CM and CWP has a strong hypoglycemic effect due to unique components present in CM and CWP