Conducting Bio IL’s Modified Alginate Synthesis and Their Biomedical Applications

Abstract

Nowadays, biomedical science faces challenges like organ failure, tissue damage due to medical problems, or cancer treatment. So, tissue engineering is a hot topic nowadays to produce or synthesize an organ using the tissue of the donor, and for this purpose, conducting polymers that can be used in making scaffolds are of the most concern. Many conducting polymers are in use for tissue engineering but they have the limitations that they are not very much cytocompatible. And they do not possess the self-property of killing bacteria or pathogens, and they are mechanically less stiff and less strong. This can restrict their application in load-bearing tissues or environments that require structural integrity. In this thesis, BIL-based modified alginate was used to make conducting polymers that are highly cytocompatible and kill cancerous cells. Additionally, these are antibacterial and that’s why can be incorporated into healing wounds. A series of choline-based ionic liquids were used to synthesize conducting polymers that are highly cytocompatible. Their synthesis was confirmed by FTIR, 1HNMR, and SEM, their mechanical properties were determined, and conducting power was calculated. These polymers were subjected to test biocompatibility against healthy (3T3) which comes out to be (80-115%), and 30-of 40% of cancer cells (HEPG2) were killed and treated in wound healing rats.