L-glycine and L-leucine-derived novel ionic liquids for potential antibacterial applications

Abstract

A total of 24 ionic liquids were prepared. Anionic components included bromide, sodium glycinate and sodium leucinate, while cationic components included imidazolium, pyridinium, quaternary ammonium, and phosphonium, tetrakis, triazolium, bicyclo cation with varied chain lengths. TLC, FTIR, and NMR were used to characterize the synthesized ionic liquids among several other techniques. The anti-bacterial activity of these samples were then tested against the potential six bacterial strains that exhibits potent antibacterial activities. The six strains include both the gram positive and gram negative bacterial strains i.e. Shigella dysenteria, Shigella boyydii, Staphylococcus aureus, Carbapenum resistant enterobacter bauminnii, Eschericia coli, Klebsella pneumonia. The majority of ionic liquids have incredible antibacterial properties. The highest antibacterial activity was reported in case of negative bacterial strains. While others also shown extremely good antibacterial properties.