Abstract:
Breast cancer is considered as one of the most frequently diagnosed cancers as it accounts for approximately 24.5% of all cases of cancer. Age, gender, family history, and smoking/alcoholism are some of the prominent risk factors for breast cancer. Since current therapeutic strategies have failed to provide fruitful outcomes in the case of advanced-stage breast cancer patients and cancer relapse is seen in most cases, therefore, management and early diagnosis are the only solutions left to control the rapidly increasing death rate. Some of the routinely used diagnostic strategies against breast cancer are regular breast examination, imaging testing, biopsy, and use of molecular biomarkers (BRCA etc). However, these already in-use strategies are much more painful, invasive, expensive, laborious, and of low sensitivity. Therefore, this study aims to investigate the role of KPCH, a member of the Kinase Protein C family, and an important molecule in the cancer signaling pathway, as an effective, precise, and sensitive biomarker that could not only aid in timely diagnosis and management of the condition but also overcome the issue of drug resistance and cancer relapse. Moreover, this study also covers the aspect of the use of biomarkers in combination to assess their correlation with some of the risk factors and clinicopathological features of breast cancer.
