Synthesis of Benzothiazole Derivatives Using Molecular Iodine as a Soft Catalyst

Abstract

The present research work entitled, “Synthesis of Benzothiazole Derivatives Using Molecular Iodine as a Soft Catalyst” describes the synthesis of benzothiazole derivatives starting from very low cost reactants. Simple route was designed in which substituted aldehydes reacted with 2-amino thiophenol. In this synthetic scheme, iodine was used as soft Lewis catalyst and the reaction was performed at room temperature and progress was monitored by TLC. Reaction was completed in very short time (3- 5 minutes). Benzoyl and Boc protection of the aldehydes was also carried out to avoid the side reaction and maximize the yield. Benzoyl protection scheme was found to be more compatible in our reaction conditions. Good to moderate yields were obtained. Melting point of all the compounds was taken and characterization was done by FT-IR and GC-MS techniques. FT-IR showed the bands for C=N that provided first indication of successful synthesis of benzothiazole molecule. Molecular ion peaks in GC-MS also supported the synthesis of required derivatives