Abstract:
In modern technological era, research in medical science has drastically increased. Cancer
is one of the most common diseases in these days and cancer treatment is most expensive
treatment which is difficult to afford for a common man. Diethylstibestrol is an artificial
estrogen whose use was limited because of the fact that a small quantity of under infusion
or over infusion can cause cardiovascular toxicity. According to a research a certain low
dose of diethylstibestrol is very effective for treatment of prostate cancer. Diethylstibestrol
is inexpensive and effective candidate when used with accurate dosage for CRPC
(metastatic castration-resistant prostate cancer) treatment and ADT androgen deprivation
therapy which are done before chemotherapy.
In this research work a descriptor system model of DES transferring in human body is
considered which is affected by some unknown exogenous input. Exogenous input is
estimated and closed loop fault tolerant nonovershooting scheme is presented for infusion
of drugs diethylstibestrol combined with aspirin. An unknown exogenous infusion input
appearing in descriptor system model of DES transfer in human body is estimated through
sliding mode observer. Nonovershooting fault tolerant tracking controller is used to remove
fault from the system model without over injection which may be caused due to
overshooting behavior.
