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Prevalence and Genotype Distribution of Human Papillomavirus (HPV) in Renal Cell Carcinoma Patients in Pakistan

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dc.contributor.author Zulfiqar, Sabahat
dc.date.accessioned 2023-09-06T07:00:01Z
dc.date.available 2023-09-06T07:00:01Z
dc.date.issued 2023
dc.identifier.other 360964
dc.identifier.uri http://10.250.8.41:8080/xmlui/handle/123456789/38283
dc.description Supervisor : Dr. Saira Justin en_US
dc.description.abstract Human papillomavirus (HPV) is the most common sexually transmitted infection. High-risk HPV (HR-HPV) strains-induced infections are associated with invasive cancer development, especially cervical cancer. HPV infections have a strong correlation with the emergence of other malignancies, including that of the oesophageal, vulva, vagina, penis, or anus. Since HPV-related renal cell malignancy is still controversial possibly due to limited data on the etiological association of HPV with renal cell carcinoma (RCC) or conflicting research results, this study was designed to investigate the prevalence of HPV and the risk of developing RCC with respect to the Pakistani population. The study included 50 healthy individuals and 48 RCC patients. The demographic data of the participants were collected with their informed consent. Blood samples from healthy individuals and tissue samples from RCC patients were collected along with their histopathological reports. DNA was extracted, and HPV testing was performed via conventional PCR. This study showed that the ubiquity of RCC is significantly greater in males (63%) as compared to females (37%). The age of 44% of patients was below 51 years, 40% of patients were between 51 and 70 years and 16% were between 71-90 years of age. Histologically, clear cell renal cell carcinoma (ccRCC) was the most prevalent type (81%). While papillary renal cell carcinoma (pRCC) and chromophobe renal cell carcinoma (chrRCC) had 7% and 6% of prevalence respectively. At Stages II and III, 38% and 33% of the cases were diagnosed respectively. Whereas, 38% and 31% of the cases were diagnosed at G2 and G1 grades respectively concluding that RCC is diagnosed at early and intermediate stages. Moreover, the prevalence of HPV was observed in 10.4% of the total RCC cases. Further confirmation and establishment of a correlation between HPV and RCC can be attained by increasing the sample size and the implementation of HPV genotype-specific testing, with particular emphasis on detecting the presence of HR-HPV genotypes, notably HPV-16, & -18. en_US
dc.language.iso en en_US
dc.publisher Atta Ur Rahman School of Applied Biosciences (ASAB), NUST en_US
dc.title Prevalence and Genotype Distribution of Human Papillomavirus (HPV) in Renal Cell Carcinoma Patients in Pakistan en_US
dc.type Thesis en_US


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