Abstract:
In current research, Carbon dots (CDs) and Au-coated Carbon dots (AuCDs) have been
synthesized using Hydrothermal and conventional coating methods. AuCDs are a novel
candidate in nanomaterials. Different characterization techniques, for instance; UV visible spectroscopy, Fluorescence spectroscopy, XRD, FTIR, SEM, and EDX have
been utilized to investigate the optical, morphological, structural, and elemental
characteristics of CDs and AuCDs. UV-visible spectroscopy, SEM, and EDX confirm
the Au coating on the surface of CDs. UV-visible spectroscopy depicts the SPR band
and broad CDs peak on Au coating. FTIR shows the existence of -OH and-COOH on
CDs’ surface which aids in the formation of AuCDs. Electrochemical biosensing of
Glucose proves the excellent sensitivity, electrical conductivity, and catalytic activity
of CDs and AuCDs. Optical detection of metal ions confirms the ability of CDs to be
used as Optical sensors for Cu ion detection. Cytotoxicity assessment on HEK-293T
and MDA-MB-231 depicts that at higher concentrations, CDs and AuCDs have higher
toxicity and are almost non-toxic at lower concentrations. Also, AuCDs show a higher
level of toxicity as compared to CDs. Thus, CDs can be utilized for the sake of
Electrochemical biosensing, Optical detection, and Cancer therapy. In addition, AuCDs
act as a novel contribution in the field of nanoparticles that can be utilized in the fields
of Electrochemical biosensing, Optical detectors, and Theranostic agents.
KEYWORDS: Carbon dots (CDs), Au-coated Carbon dots (AuCDs), Electrochemical
biosensing, Glucose, Optical detection, Cytotoxicity
