Abstract:
Liver cancer is one of the leading causes of mortality around the world. Over the years various biomarkers
have been identified which can play a role in the detection and treatment. But there remains an urgent need
for novel, more specific and effective biomarkers that can help in the detection of liver cancer. KLF3 gene
expression has previously been associated with cancer development as suggested by previous studies where
its role has been implicated in cancer signalling pathways. This study aims to investigate the expression
levels of KLF3 and its pathogenicity in liver cancer by analysing single nucleotide polymorphisms (SNPs),
predicting its three-dimensional structure, examining subcellular localization, and assessing its interactions
with other proteins. The study demonstrates a significant association of pathogenic non-synonymous KLF3
SNPs with liver cancer by analysing genotyping data from liver cancer patients and healthy controls, where
the highest frequency distribution was reported by the homozygous genotype in patient samples. The study
also examines patterns in relative expression of biomarkers of the gene KLF3, their correlation with various
clinical features as well as risk factors associated with liver cancer. The study lays the foundation that KLF3
gene expression has a significant role in carcinogenesis as its overexpression is associated with
hepatocellular carcinoma.
