Design and Analysis of Multimodal Piezoelectric Ultrasound Transducer for Cancer Cells Bursting

Abstract

Cancer research has been a significant concern for researchers globally owing to the tremendous loss of life caused by various kinds of cancer cells. Traditional cancer treatments, such as chemotherapy, can have severe adverse impacts on the human body. Ultrasound bursting is a unique technique that produces powerful, short-duration ultrasound pulses. When such pulses are focused on specific target cells, they can cause localized effects such as cavitation, acoustic streaming, and thermal ablation. This study suggests a new multi-modal piezoelectric ultrasonic transducer design for the bursting of many types of cancer cells. The design consists of three dual-band piezoelectric ultrasound transducers that generate resonance frequencies of 80, 120, 150, 180, 250, and 300 kHz that have been carefully selected for various types of cancer cells. The generated resonance frequencies will resonate with cancer cells and burst them when resonance-induced vibrational energy increases a certain limit. The design and analysis of the transducer were carried out in COMSOL Multiphysics and the results show focused ultrasounds with a maximum sound pressure level of 200 dB a biocompatible piezoelectric material is required for direct contact with biological tissues without causing harm or inducing adverse reactions while also having low acoustic impedance and impedance matching with the human tissue is required for this purpose.