The Healing Effect of Fagonia Indica and Coriandrum Sativum on Second Degree Burn Wounds in Rat Models

Abstract

Burn wounds are among one of the most common and disturbing infirmities of the body, which in many cases cause permanent disabilities. Treating these injuries so that they heal faster and preventing them from infection remains a challenging area of medical research. Current available synthetic burn treatments produce adverse effects such as erythema and pruritis which pose a hindrance in burn treatment. For this purpose, Coriandrum sativum and Fagonia indica extracts were proposed to formulate a gel that could be used as an organic alternative. Extracts from plants were obtained using Soxhlet apparatus and maceration. The plant extracts were lyophilized and used to formulate gels; 5% coriander gel, 5% fagonia gel, 5% corainder and fagonia gel and 5% coriander and fagonia gel in a known antimicrobial base. The gels were then used to treat second degree burns induced on rats via dry heat. The antimicrobial activity, skin irritant ability and burn wound healing competencies of gels were determined. Wound healing capacity was calculated by comparing the decrease in wound size on alternate days. In silico analysis was carried out to further corroborate the results. It was concluded that the 5% coriander gel was the most efficacious in healing of burn wounds due to its superior antioxidant concentration and its activity was comparable to the standard clinical treatment (Silver sulfathiazole).