An Appraisal of Wound Condition Mediated Drug Release by Comparing Two Hydrogel Systems

Abstract

Topical, sustained drug delivery according to the physiological need at the wound site enhances the healing rate of chronic wounds. Natural (Chitosan-Gelatin) and semi-synthetic (2-Hydroxyethyl Methacrylate-Gelatin) types of hydrogel complexes were prepared and tested to form flexible wound dressings. They smartly respond to the pH changes in wound by releasing drug accordingly, aiding in fast healing and successful wound management. The morphological and mechanical properties of hydrogels were determined using various characterization techniques, that comply with the in-vitro experimentation, which includes drug release pharmacokinetics, degradation profiles and anti-microbial study. Further, in-vivo studies were performed on mice models to test the efficacy of wound dressings.