Synthesis and Characterization of Etoposide Loaded Nanostructured Lipid Carriers and Their Targeted Delivery to Cancerous Cells

Abstract

Etoposide (ETP) is one of the most widely used drugs for the treatment of many forms of cancer. The main target of Etoposide is Topoisomerase-II, hence the name Topoisomerase-II Inhibitor. But its low solubility causes slow and less effective therapeutic response in patients, so to overcome these drawbacks, the liposomal nanoparticles are being used owing to their large surface area and ability to deliver drugs through cell membrane. ETP loaded Liposomal, prepared by “Thin Film Hydration” method, were characterized with the help of different characterization techniques. The Release Kinetics of particles was evaluated by Drug Diffusion method, the slow release of drug from nanoparticles. ETP-LIP showed significantly improved properties as compared to Blank Liposomes and Etoposide. Improvement of ETP-LIP with attachment of proteins which have their receptor on cell surface, would make them target specific with minimal exposure to normal cells and with enhanced activity so a small amount of drug results in more toxicity in cancerous cells.