Analysis of Eae Model for The Development of Therapies of Multiple Sclerosis Through Bioinformatic Tools

Abstract

Multiple Sclerosis is an autoimmune demyelinating inflammatory disease of the central nervous system (CNS) which resulted in the severe neurological defects. Mostly MS affected the adult life in their early life and it shows huge affect on family, and on professional and on daily life. The rate of multiple sclerosis according to some research in women is four times higher than in man, though the exact reason of this is still unclear but the researchers associated this with the difference in sex that linked with the brain in the MS. The disease progression of multiple sclerosis and its developments entails fundamental steps: (1).The destruction of myelin sheath and formation of lesions, (2).Inflammation. These steps are communicated together in a collaborative way, destroying the neuron tissues and causing MS. The goal of the research is to develop the EAE model for the identification of proteins involved in Multiple Sclerosis and then develop the interventions that can improve the lives of those living with MS. Synaptosomal-associated protein 25 (SNAP-25) is a 25kD protein with 206 amino acids. The pre-synaptic terminal of neurons is composed of a t-SNARE or target SNARE molecule. Formation of neural soluble Nethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes occurs because of SNAP -25 and has a great importance. Calcium-dependent exocytosis of synaptic vesicles, proper efficient release of neurotransmitters and propagation of action potential is done by SNARE complex. The normal levels of SNAP-25 are mandatory for neurotransmission; the changes in its expression can cause many disorders including autoimmune disorder like Multiple Sclerosis. The ultimate goal of this research is to assess the behavioral changes and pathophysiology of MS.