Administration of Fluoxetine incorporated Liposomal Nanoparticles in Chronic Mild Stress (CMS) Animal Model for the treatment of Depression

Abstract

Depression is one of the most severe disorder that is affecting people all over the world. Stomach upsetting, headache, nausea, breathing problems all linked to depression symptoms. Depression must be addressed because it leads to a low energy level and reduced work productivity in a person. Antidepressants such as Fluoxetine are commonly used medication to change chemicals in the brain known as serotonin, dopamine, and norepinephrine. These chemicals are involved in monitoring and controlling mood swings in a person. However, the Blood-Brain Barrier (BBB) plays an essential and significant hurdle in transporting antidepressants to the nervous system. Nanotechnology has provided the solution and enhances the targeted drug delivery to the nervous system. In this research work, Fluoxetine incorporated liposome nanoparticles were fabricated and developed to transport the drug (Fluoxetine in this case) across the BBB to the nervous system with high efficiency. A mice model of depression, 'Chronic Mild Stress (CMS),' was made, and depression was induced in mice to test the drug delivery efficacy. Drug was successfully targeted to the brain. Hence, it's proved to be the best treatment procedure because of testing.