Abstract:
Biodegradable polymer-based drug loaded films and composite were prepared as potential anti-coagulant coating for the application of cardiovascular implants for the treatment of thrombosis. Cinnamon Cassia, Ocimum tenuiflorm and Panax Ginseng are pharmaceutically active in many ways, having properties such as anti-coagulation, anti-oxidative activity and can be used to treat thrombosis after implantation of cardiovascular implants. For this purpose, Drug loaded films were fabricated using solvent casting method and PLA (Poly lactic acid) was used as drug carrier and above-mentioned drugs were used as anti-coagulant drugs. The surface morphology and chemical compositions of coatings were analyzed by Scanning electron microscopy (SEM) and Fourier transform infrared region (FTIR). In this study, In vitro anticoagulation activity, drug release studies, degradation studies, hemocompatibility and anti-oxidative studies of coatings were investigated. In vitro anti-coagulation activity of coating films was checked by a-PTT and PT test and drug composite indicated anti-coagulation activity equals to commercially available anticoagulant drug and anti-coagulation behavior of coating films was improved as the concentration of drug was increased. Drug release and degradation behavior of drug composite were almost same to commercially available anti-coagulant drug. In addition, drug composite exhibited high anti-oxidative and non-hemolytic activity. To conclude, the results of the present study showed that drug composite has a potential application as anti-coagulant coating for cardiovascular implants.
