Abstract:
Type 2 Diabetes Mellitus (T2DM), a kind of Diabetes Mellitus (DM), is emerging as
a challenging global epidemic. Hyperglycemia is the hallmark of T2DM and the
major factors regulating the metabolism of glucose in the body are Insulin Production
from pancreatic β-cells and Insulin Resistance (IR) of target tissues. Current
therapeutic options pose certain side effects. After the ineffectiveness of chemically
synthesized compounds, the world has come to explore natural resources for the
purpose of treatment and pain alleviation once again. Cestrum diurnum is a shrub
grown in several parts of the world for ornamental purposes and it is being in use
since ages in traditional medicine. To investigate the anti-diabetic property of
Cestrum diurnum, this study is had been directed. Phytochemical and biochemical
assays were performed which reveals the in-vitro biochemical activities and
phytochemical constituents of ethanolic extract of Cestrum diurnum leaves. To check
the restorative impact of Cestrum diurnum, in-vivo study on BALB/c mice models
was conducted. Mice were administered different doses of plant extract after diabetes
induction. Diabetes was induced by combination of high fat diet and streptozotocin.
Treatment with Cestrum diurnum was found to be significantly effective in managing
hyperglycemia and improving glucose in mice models.
