Therapeutic Evaluation of Cestrum diurnum Extract for the Treatment of Diabetes Mellitus Type 2

Abstract

Type 2 Diabetes Mellitus (T2DM), a kind of Diabetes Mellitus (DM), is emerging as a challenging global epidemic. Hyperglycemia is the hallmark of T2DM and the major factors regulating the metabolism of glucose in the body are Insulin Production from pancreatic β-cells and Insulin Resistance (IR) of target tissues. Current therapeutic options pose certain side effects. After the ineffectiveness of chemically synthesized compounds, the world has come to explore natural resources for the purpose of treatment and pain alleviation once again. Cestrum diurnum is a shrub grown in several parts of the world for ornamental purposes and it is being in use since ages in traditional medicine. To investigate the anti-diabetic property of Cestrum diurnum, this study is had been directed. Phytochemical and biochemical assays were performed which reveals the in-vitro biochemical activities and phytochemical constituents of ethanolic extract of Cestrum diurnum leaves. To check the restorative impact of Cestrum diurnum, in-vivo study on BALB/c mice models was conducted. Mice were administered different doses of plant extract after diabetes induction. Diabetes was induced by combination of high fat diet and streptozotocin. Treatment with Cestrum diurnum was found to be significantly effective in managing hyperglycemia and improving glucose in mice models.