Green Synthesized Silver Nanoparticles Enhances Anticancer Activity of HDAC Inhibitor Panobinostat

Abstract

Breast cancer is the most common cancer among women even though numerous treatment options for breast cancer have been documented. Panobinostat, A histone deacetylase inhibitor, modifies gene expression through epigenetic pathways and prevents protein breakdown. The focus of this study is to enhance drug distribution to the tumor site and boost the efficiency of Panobinostat by using silver nanoparticles as controlled drug delivery system. Here we report the green synthesis of silver nanoparticles by using Rhazya stricta extract, as a nanocarriers for drug delivery. These drugs loaded nanoparticles were characterized by UV-Vis spectroscopy, XRD, FTIR, SEM, and EDX techniques. The overall findings demonstrated that AgNPs synthesized through Rhazya stricta has the high potential for sustained release of Panobinostat for cancer therapy. As the successfully synthesized Panobinostat-AgNPs were stable and exhibited increased in vitro anticancer activity compared with free Panobinostat, our data demonstrate that the combination of AgNPs with Panobinostat improves the drug's long-term viability, effectiveness, and active targeting as a potential targeted therapeutic molecule for the treatment of cancer. To strengthen the utilization of this combination therapy in cancer therapy trials, further research is warranted.