Synthesis of the MOF derived Nano-Particles and their Electrochemical Sensing of Dopamine

Abstract

DA is a very important neuro modulator, and is involved in brain circuitry mechanism. And also serves as precursor for other molecules/ hormones like epinephrine etc. It exists as a large cation in blood, its detection within body is important because its different concentrations are responsible for different daily routine activities like feelings, hunger pain, emotions. A lot of work is carried out in designing and fabricating techniques for selective DA detection. I have synthesized Hf-BDC MOF by simple heating of their salt solutions in glass vials. Composites was prepared by physio-sorption of Co (acac)3 precursor inside the MOF cavities. Thermal treatment results in the formation of NPs that are tested for DA detection along with parent materials. Synthesized NPs were characterized by XRD, SEM, EDS, HR-TEM, XPS and sensing applications were carried out with CV, LSV and DPV. Response was observed in the form of oxidation peak and was observed that peak current increases with increasing DA concentration. Linear range was observed between 2.5μM-650μM with DPV while 0.25mM-3.14mM with CV and LSV. LOD calculated to be 18.39nM and LOQ came out as 61.38μM with electrode sensitivity of 8.34μAcm-2.