Abstract:
The purpose of this study was to prepare aqueous coated tablets of famoscot, having famotidine
as active ingredient of tablet. In commercial manufacturing of famotidine tablets organic solvents
had been used, which were hazardous not only for people working in industries but also for
environment, residual solvents in drug were also harmful to patients. In this research work, in order
to overcome this drawback organic solvents were replaced with water. For this purpose core of
tablets having famotidine were prepared by direct compression method, evaluation tests were
performed. This core was coated by varying amount of different polymers i.e. HPMC, PVA and
PVP. It was observed that best coating was done using a blend of HPMC and PVA. The coated
tablets were evaluated for hardness, weight variation, friability, in vitro dissolution and uniformity
of content, obtained results showed that all parameters were within USP limits. FTIR was also
done to check drug and polymer interaction, UV-Visible spectroscopy was used for dissolution
studies. The formulation prepared by using blend of HPMC and PVA had no visual defects. IR
studies of PVA and HPMC showed that no interaction had been observed between polymer and
famotidine. Its disintegration time was also 1 minute, assay and dissolution time was 98%. Further,
selected formulation was also subjected to accelerated stability studies and tablet remained stable
for 6 months.All the obtained results of aqueous coated famotidine tablets fulfilled the criterion of
the USP, by the replacement of organic solvents with water they will be expected to have no side
effects caused by organic solvents and can be used commercially.
