Optimization and Evaluation of Aqueous Coating of Famotidine

Abstract

The purpose of this study was to prepare aqueous coated tablets of famoscot, having famotidine as active ingredient of tablet. In commercial manufacturing of famotidine tablets organic solvents had been used, which were hazardous not only for people working in industries but also for environment, residual solvents in drug were also harmful to patients. In this research work, in order to overcome this drawback organic solvents were replaced with water. For this purpose core of tablets having famotidine were prepared by direct compression method, evaluation tests were performed. This core was coated by varying amount of different polymers i.e. HPMC, PVA and PVP. It was observed that best coating was done using a blend of HPMC and PVA. The coated tablets were evaluated for hardness, weight variation, friability, in vitro dissolution and uniformity of content, obtained results showed that all parameters were within USP limits. FTIR was also done to check drug and polymer interaction, UV-Visible spectroscopy was used for dissolution studies. The formulation prepared by using blend of HPMC and PVA had no visual defects. IR studies of PVA and HPMC showed that no interaction had been observed between polymer and famotidine. Its disintegration time was also 1 minute, assay and dissolution time was 98%. Further, selected formulation was also subjected to accelerated stability studies and tablet remained stable for 6 months.All the obtained results of aqueous coated famotidine tablets fulfilled the criterion of the USP, by the replacement of organic solvents with water they will be expected to have no side effects caused by organic solvents and can be used commercially.