Abstract:
Depression is one of the most increasing psychological mood disorders, depression does not have some specific physical symptoms, but it negatively affects the person mood, way of living and thinking chronic mild stress (CMS) is one of its type, depression is affecting more than 300million people in the world. Shortness of breath, headache, being miserable, stomach disturbance and physical tensions are some of the common symptoms of depression that is reported according to National Alliance of Mental Health, Anti-depressant are used for altering the neurotransmitters those are serotonin, dopamine and norepinephrine that are primarily involved in regulating and mood alleviating mood. Despite the availability of large number of drugs, many of patients are resistant to the current mode of treatment that are available now adays. The obstacle that is significant for the transportation of beneficial therapeutic entities to the nervous system is BBB that is the blood brain barrier. There are junctions that are present in the endothelial cells of the blood brain barrier that stop the drugs passage. Now nanoparticles are receiving significant limelight owing to their small size and efficient brain targeting activity, making them likely to cross the blood brain barrier while carrying the intact drug molecule otherwise incapable of permeation. In this study the fluoxetine loaded liposomal nanoparticle coated with PEG were developed to transport the drug across the BBB to the central nervous system having much greater efficiency. For testing its delivery, the animal that is mice model of depression is used with the specific name that is designed in order to induce depression like symptoms in mice. Before and After treatment great differences between the physical behaviors like Elevated maze, open field test, force swim test etc and sucrose consumption test were identified and plotted, as liposomes that having capabilities to carry the anti-depressant drug molecule that is administered through the Oral route of administration or the better and improved method of treatment
