Abstract:
Breast cancer is one of the most common and frequently occurring malignancy in women
around the world, responsible for reported increase in death incidence. Both genetic and non genetic factors are involved in the onset and progression of breast cancer. KPCD belongs to
novel KPC of the AGC kinases that plays a pivotal role in the development and progression of
different cancers. A few studies have reported that KPCD can promote and suppress tumor
progression depending on the interaction with its downstream signaling proteins. To date, there
is no published data that define the correlation of KPCD with other genes in breast cancer
progression. Therefore, the objective of the study is to evaluate the impact of KPCD protein protein interaction in cancer progression and to find the association of blood-based interaction
of KPCD with clinical parameters. The study has reported the three-dimensional structure
prediction and validation, evolutionary analysis, and conservational analysis of KPCD.
Molecular dynamics analysis has revealed that the interactions between KPCD and SMAD3
for the mutated structure was less stable as compared to the native KPCD and SMAD3
interactions, which may contribute to the cancer progression. This study also evaluates the co expression of KPCD, TGF-B, and SMAD3 in the blood breast cancer patients. The study
reported the elevated expression status of all three genes in breast cancer patients that may be
serve as a potential biomarker for cancer diagnosis and treatment.
