Development and Characterization of DNA-based Kit for Cancer Diagnosis

Abstract

Cancer impermanence and the incidence rate is increasing gradually. Cancer costs us not only economically but also our beloved ones. Different treatments are available to combat cancer propagation. The effectiveness of the treatment is directly related to the diagnosis of cancer. The earlier the cancer diagnosis, the earlier the treatment begins. Various types of diagnostic methods for cancer are available, but all those deal with the later stages of cancer. Moreover, they are specific to one type of cancer. In this study, we tried to design a biosensor that can detect cancer at its earlier stages. The biosensor simply consists of graphene that acts as a transistor, a linker that makes the connection between the graphene and antibodies that capture the biomarker of cancer. Metal electrodes are present at both ends of the graphene. We immobilized the antibodies on the sensor, but we haven’t attained the current-voltage shift produced in response to the binding of cancer biomarkers to the antibodies. A lot remains yet to explore in this domain.