Dysfunctional Glucose Metabolism and Progression of Alzheimer's disease

Abstract

Alzheimer's disease (AD) is the degenerative brain disorder, which is the most common form of dementia resulting in progressive memory loss, impaired thinking and brain degeneration.In cerebral cortex the neurons degenerated and demonstrated the emergence of neurofibrillary tangles and plaques containing β amyloids. Glucose is an essential energy substrate to sustain neuronal activity and is taken up via glucose transporters expressed in the brain endothelium, astrocytes and neurons.Emerging evidence suggests that impaired cerebral glucose metabolism, deposition of Aβ aggregates, oxidative damage, results in thinning of key brain areas, which is invariant pathological feature of AD. The main objective of this study was to find interactive association between glucose metabolism and AD progression.Furthermore identification of differentially regulated proteins involved in glucose metabolic pathway and to further characterize the therapeutic intervention towards AD progression.In this study we found eight dysregulated glucose linked proteins with AD.