Abstract:
Parkinson’s disease is a neurodegenerative disorder that is linked with the loss of dopaminergic
neurons of the substantia nigra pars compacta. In this disease, many projecting nerve fibers
present in striatum are degenerated. Currently no efficient therapy is present to delay the
neurodegenerative process, so modification of the neuro-protective therapy is critical clinical
requirement. Saikosaponin B3 is a bioactive phytochemical of Bupleurum marginatum and B.
falcatum. The structure, anti-cancer and anti-oxidative activities of Saikosaponin B3 have been
discovered. This research is designed to evaluate the effect of anti-oxidative activity of
Saikosaponin on Parkinson’s disease as it is expected to attenuate the oxidative stress by
increasing the activity of anti-oxidative enzymes. This study highlights the associated
mechanism and interaction with pathways during neuro-protection therapy. MPTP-induced
balb/c mice will be used as a model and the neuron response will be checked and evaluated after
dosage of Saikosaponin B3 by EEG assesment. Later, the brain cells were isolated, purified and
the activity was analyzed completely
