Abstract:
Modified nucleosides are biologically and chemically active, due to which it shows array
of pharmaceutical applications e.g anti-cancer, anti-fungal, anti-influenza, antimicrobial,
anti-inflammatory, anti-viral, anti-malarial, anti-dengue, anti-bacterial, antidiabetic,
enzyme inhibitors and anti-oxidant. These molecules are attracted as a versatile
nucleus in the field of medicinal and pharmaceutical Chemistry in recent years. In
present research work base modified nucleoside were synthesized from 3-acetyl indole
and indole by using anhydrous stannous chloride (SnCl4). Synthesized modified
nucleoside analogues were characterized by physical and spectroscopic techniques like
FT-IR, GCMS, LC-MS, 1H and C13 NMR. Alzheimer is the most common cause of
dementia and it is due to the presence of acetylcholinesterase enzyme superfluity.
Acetylcholinesterase enzyme inhibition activity of synthesized compound was checked.
The synthesized nucleoside, 3-acetyl indole nucleoside showed promising biological
activity for the suppression of acetylcholinesterase. Anticancer activity was also checked
against Colorectal Carcinoma Cell line HCT-116 of synthesized compounds. Acetylated
xylose showed 51 % anticancer activity.
