Synthesis of Modified Nucleosides

Abstract

Modified nucleosides are biologically and chemically active, due to which it shows array of pharmaceutical applications e.g anti-cancer, anti-fungal, anti-influenza, antimicrobial, anti-inflammatory, anti-viral, anti-malarial, anti-dengue, anti-bacterial, antidiabetic, enzyme inhibitors and anti-oxidant. These molecules are attracted as a versatile nucleus in the field of medicinal and pharmaceutical Chemistry in recent years. In present research work base modified nucleoside were synthesized from 3-acetyl indole and indole by using anhydrous stannous chloride (SnCl4). Synthesized modified nucleoside analogues were characterized by physical and spectroscopic techniques like FT-IR, GCMS, LC-MS, 1H and C13 NMR. Alzheimer is the most common cause of dementia and it is due to the presence of acetylcholinesterase enzyme superfluity. Acetylcholinesterase enzyme inhibition activity of synthesized compound was checked. The synthesized nucleoside, 3-acetyl indole nucleoside showed promising biological activity for the suppression of acetylcholinesterase. Anticancer activity was also checked against Colorectal Carcinoma Cell line HCT-116 of synthesized compounds. Acetylated xylose showed 51 % anticancer activity.