Synthesis of Modified PVA Derivatives Containing Silver Nanoparticles for Wound Healing Applications

Abstract

Different types of pathogens are present in our environment that causes infection in wounds. A lot of antibiotics have been synthesized for killing these pathogens, but their excessive use makes them drug resistant. That is why we are in need of new bacterial resistant materials, which will help us in overcoming this problem. Polymers have proved their worth in every field of life. Different derivatives of Polyvinyl Alcohol (PVA) have been reported to show antibacterial properties and they have been previously used for wound healing applications. Along with polymers, nano-particles are widely used in biological application. In this work amine derivative of PVA has been synthesized. Along with this, silver nano-particles were synthesized using amine derivative of PVA as a stabilizing agent. Final product was casted into films, which are easier to apply on wounds. Comparative analysis of these films was done as films were prepared in different concentration of nano-particles. The produced materials were characterized through different characterization techniques: UV/vis Spectrophotometry, FTIR, NMR, SEM, XRD, and EDX. Further anti-bacterial activities of these films was checked which showed good results, with silver nano-particles synthesized by PVA derivative as stabilizing agent showing maximum activity.