Abstract:
The present research work deals with the synthesis of Schiff bases derived from Isoniazid
and different aldehydes. Nine different ligands were synthesized by using variously
substituted aldehydes. Benzoyl and Boc protection of the aldehyde were also carried out
where necessary. The ligands were characterized by the melting point, FT-IR and GC-MS.
After that synthesized ligands were used for complexation reaction by using metal halide
salt i.e. NiCl2.6H2O. All the synthesized complexes were characterized by melting point,
FT-IR and UV-vis spectroscopy. The biological activity of the ligands as well as
complexes was checked against Colorectal Carcinoma cell line HCT-116 and all the
compounds show activity against cell line. The activity against cell line was carried out
using four different dilutions and all the compounds were even active up to the fourth
dilution.
