Synthesis and Biological Activities of Metal Complexes of Schiff Bases Synthesized from Isoniazid

Abstract

The present research work deals with the synthesis of Schiff bases derived from Isoniazid and different aldehydes. Nine different ligands were synthesized by using variously substituted aldehydes. Benzoyl and Boc protection of the aldehyde were also carried out where necessary. The ligands were characterized by the melting point, FT-IR and GC-MS. After that synthesized ligands were used for complexation reaction by using metal halide salt i.e. NiCl2.6H2O. All the synthesized complexes were characterized by melting point, FT-IR and UV-vis spectroscopy. The biological activity of the ligands as well as complexes was checked against Colorectal Carcinoma cell line HCT-116 and all the compounds show activity against cell line. The activity against cell line was carried out using four different dilutions and all the compounds were even active up to the fourth dilution.