Abstract:
Complex formation in pharmaceutical chemistry improves the pharmacological and
physico-chemical properties of drugs. Twelve novel ternary metal complexes of
biologically important ligands quinolones and glycine have been synthesized and
characterized by FT-IR and UV-vis. Quinolones act as primary ligand and glycine act as
secondary ligand. General formula of complexes is [M(MOX)(Gly)(H2O)2],
[M(LEV)(Gly)(H2O)2], [M(CIP)(Gly)(H2O)2] where M = Ni(II), Cu(II) and
[M(MOX)(Gly)(H2O)2]Cl, [M(LEV)(Gly)(H2O)2]Cl, [M(CIP)(Gly)(H2O)2]Cl where M
= Fe(III), Co(III) with octahedral structure. Density functional theory (DFT) is used to
optimize the geometry, bond length, bond angle and stable energy of complexes. In-vitro
antimicrobial activity of ternary complexes was measured higher than reference drugs
ciprofloxacin and kanamycin. Also, these complexes were screened for cytotoxicity and
the results showed that all complexes are non-toxic. So, these results indicated that after
further studies these complexes may be proved as lead compounds to be used as
effective antibiotic drugs.
