Synthesis, DFT Study and Biological Activities of Ternary Metal Complexes Using Quinolones With Amino acid

Abstract

Complex formation in pharmaceutical chemistry improves the pharmacological and physico-chemical properties of drugs. Twelve novel ternary metal complexes of biologically important ligands quinolones and glycine have been synthesized and characterized by FT-IR and UV-vis. Quinolones act as primary ligand and glycine act as secondary ligand. General formula of complexes is [M(MOX)(Gly)(H2O)2], [M(LEV)(Gly)(H2O)2], [M(CIP)(Gly)(H2O)2] where M = Ni(II), Cu(II) and [M(MOX)(Gly)(H2O)2]Cl, [M(LEV)(Gly)(H2O)2]Cl, [M(CIP)(Gly)(H2O)2]Cl where M = Fe(III), Co(III) with octahedral structure. Density functional theory (DFT) is used to optimize the geometry, bond length, bond angle and stable energy of complexes. In-vitro antimicrobial activity of ternary complexes was measured higher than reference drugs ciprofloxacin and kanamycin. Also, these complexes were screened for cytotoxicity and the results showed that all complexes are non-toxic. So, these results indicated that after further studies these complexes may be proved as lead compounds to be used as effective antibiotic drugs.