Abstract:
Drug delivery system has been used to control the release of drug within the body by carrying
the drugs through drug matrices. SBA-15 being a mesoprous material has been effectively
used for drug delivery system. The synthesized SBA-15 was functionalized with APTES by
post grafting method to improve its drug release mechanism. For this purpose, Cloxacillin has
been used for the very first time, as a model drug for loading on mesoporous materials.
Characterization techniques have been used for analysis includes small angle XRD, FTIR,
SEM, BET for determining the surface morphology and surface area and porosity. These
techniques confirmed the porosity and successful functionalization of silica. Surface
functionalization caused the decrease in pore size from 5.1 nm to 4.6 nm, surface area from
534 m2/g to 163 m2/g and pore volume 0.036 cm3/g to 0.015 cm3/g and showed the slow and
sustained release of cloxacillin as compared to pure silica. By measuring the concentration
difference, drug loading and release was calculated. Results demonstrated that 5% of the drug
has been loaded on pure SBA-15 and drug loading efficiency decreased up to 3% for
modified material. The decrease in loading amount is because of the decreased in surface area
and pore size as compared to pure sample. Drug Release experiments confirmed that
modified material showed slow and sustained release than un-modified material.
