Synthesis and Characterization of Mesoporous SBA-15 and Modified SBA-15 for Application in Controlled Drug Delivery of Cloxacillin

Abstract

Drug delivery system has been used to control the release of drug within the body by carrying the drugs through drug matrices. SBA-15 being a mesoprous material has been effectively used for drug delivery system. The synthesized SBA-15 was functionalized with APTES by post grafting method to improve its drug release mechanism. For this purpose, Cloxacillin has been used for the very first time, as a model drug for loading on mesoporous materials. Characterization techniques have been used for analysis includes small angle XRD, FTIR, SEM, BET for determining the surface morphology and surface area and porosity. These techniques confirmed the porosity and successful functionalization of silica. Surface functionalization caused the decrease in pore size from 5.1 nm to 4.6 nm, surface area from 534 m2/g to 163 m2/g and pore volume 0.036 cm3/g to 0.015 cm3/g and showed the slow and sustained release of cloxacillin as compared to pure silica. By measuring the concentration difference, drug loading and release was calculated. Results demonstrated that 5% of the drug has been loaded on pure SBA-15 and drug loading efficiency decreased up to 3% for modified material. The decrease in loading amount is because of the decreased in surface area and pore size as compared to pure sample. Drug Release experiments confirmed that modified material showed slow and sustained release than un-modified material.