Abstract:
Catheter Associated Urinary Tract Infections (CAUTIs) are a major healthcare concern and are
linked to the use of indwelling urinary catheters. In this study, we present an approach for the
prevention and treatment of CAUTIs by developing ceftriaxone-containing chitosan-coated
catheters. Chitosan, a biocompatible and antimicrobial polymer, was utilized as a coating material
for urinary catheters. Additionally, Ceftriaxone, a potent broad-spectrum antibiotic, was
incorporated into the chitosan coating to establish a dual-action mechanism against UTI-causing
pathogens. The uropathogens accumulate around the catheter surface and form biofilms which are
sometimes very difficult to remove. The chitosan coating acts as a physical barrier, inhibiting
bacterial adhesion and subsequent biofilm formation on the catheter surface. In vitro studies were
conducted to assess the antimicrobial efficacy of ceftriaxone-containing chitosan-coated catheters
against common uropathogens i.e., Staphylococcus aureus and Escherichia coli. Results of
ceftriaxone containing chitosan-coated catheters in the form of Zone of Inhibition demonstrated
better results as compared to uncoated catheters. Furthering up the research by taking in some
other uropathogens and with further degradation, toxicity as well as surface morphological
analyses effectivity of catheters can be enhanced.
