Synthesis And Characterization of Superparamagnetic Iron Oxide Nanoparticles For Drug Delivery Applications

Abstract

Metal–organic frameworks, generally referred to as MOFs, are a type of porous hybrid material that is made of metallic cations and organic ligands. These frameworks are being extensively examined in many possible applications. In the present investigation, magnetic metal-organic frameworks (MOFs) have been synthesized for the very first instance with the objective of facilitating drug delivery. The production of MOFs that can enclose superparamagnetic Fe3O4 nanoparticles has been made possible by the development of a generic coprecipitation process that can be carried out in situ in a single step. The incorporation of Fe3O4 nanoparticles into MOFs results in the display of numerous fascinating intrinsic features, such as a porous nature, simple functionalization, and potent superparamagnetism. In this example, Ciprofloxacin drug has been covalently linked to amino-rich magnetic MOFs. The field emission scanning electron microscopy (FESEM), the Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) are used to analyze the magnetic MOFs that are produced as a result of this process. Drug loading was characterized by UV-VIS spectroscopy. XRD showed formation of magnetite, MOF, and functionalized magnetic MOF. SEM images confirm the formation of magnetic MOF loaded with different amount of nanoparticles. FTIR analysis confirms the loading of drug into the functionalized magnetic MOF. Increased drug loading is observed in the case of high loaded MOF having encapsulation efficiency of 87%, which also shows good drug release rate.