Systematic Evaluation of Natural Compounds of Thymus serpyllum and Cassia angustifolia to Identify Potential Targets for Rheumatoid Arthritis

Abstract

Auto Immune are characterized by a wide variety of risk factors, which might include nutritional, environmental, and genetic variables. An autoimmune condition with a complicated origin is rheumatoid arthritis (RA). Rheumatoid Arthritis being treated majorly byNSAIDS, DMARDS, Glucocorticoids and Biologics, needs improvement in the therapy. Natural compounds from various plants have been used for centuries to cure various diseases owing to their fewer side effects. This study focuses on the natural compounds extracted fromThymus serpyllum and Cassia Angustifolia for their anti- rheumatic potential. The active phytochemicals of both the plants showed excellent characteristics to be used an anti-arthritic agent.as seen through DPPH Assay. The compounds from T.serpyllum and C. Angustifolia were screened for their potential targets against Rheumatoid Arthritis. The insilico docking analysis of phytochemicals and commercial drugs with potential targets of Rheumatoid Arthritis predicts a good binding energy to be a potential therapy substitute in comparison to the drugs available in the market with various side effects.