Imidazolium-based bi-ionic liquid and Ag nanoparticles modified sodium alginate hydrogel films for investigating wound healing and antibacterial efficacy

Abstract

In order to make advances in the area of biomedical engineering and to improve its therapeutic and diagnostic domain, novel materials are required that can imitate the complexity of biological tissues. Because of the high water content and biocompatibility of hydrogels, they are being considered for a wide range of medical applications. This dissertation investigates the synthesis and bio-activity of alginate hydrogel and its crosslinked derivative in biomedical territory. A series of alginate films and p-phthaloyl crosslinked alginate films were modified with imidazolium-based bi-ionic liquid and green synthesized silver nanoparticles. Their synthesis was confirmed by different techniques such as FTIR, XRD, 1 HNMR, and SEM. Moreover, their mechanical and thermal properties were also studied with different parameters. These polymers were subjected to test anti-bacterial activity against five different strains of bacteria including both gram-negative and gram-positive bacteria. The results showed that the hydrogel films incorporated with ionic liquid showed good activity and crosslinked films with the combination of both ionic liquid and silver nanoparticles showed good results.