SYNTHESIS OF STRONTIUM DOPED IRON OXIDE NANOPARTICLES FOR DRUG DELIVERY APPLICATIONS

Abstract

Iron oxide nanoparticles has been one of the most researched materials for biomedical application, especially drug delivery due to its incomparable properties like magnetic nature (superparamagnetism), biocompatibility, availability (abundance) and ease of synthesis. This research focuses on the synthesis of magnetite nanoparticles and strontium doped Iron oxide nanoparticles for drug delivery applications through hydrothermal and coprecipitation route. Ibuprofen is used as an anticancer drug which is loaded on these bare nanoparticles (Fe3O4 and strontium doped Iron oxide nanoparticles). These prepared nanoparticles were characterized by X-ray powder diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive X-ray (EDX), Fouriertransform infrared spectroscopy (FTIR), Vibrating Sample Magnetometer (VSM) and UV Vis spectroscopy (UV). Drug loading is characterized by UV-vis Spectroscopy whereas cytotoxicity of both nanoparticles and drug loaded nanoparticles are analyzed by MTT Assay. XRD results showed formation of both magnetite and strontium doped Iron oxide nanoparticles and showing the relevant peak of synthesized nanoparticles both