Ch/nHA/ZnO Coated Surgical Staple Pins for Enhanced Corrosion Resistance and Antibacterial Performance

Abstract

Surgical Staple Pins (SSPs) play a significant role during the wound healing of surgical site infection in the medical world. This project focuses on enhancing the biocompatibility and performance of surgical staples through the synthesis of a specialized coating. Surgical staples are widely used in various medical procedures for wound closure and tissue approximation, offering advantages such as speed, consistency, minimal tissue reaction, and reduced scarring. However, to further improve their effectiveness, we aimed to develop a coating with specific properties. The selected materials for the coating include chitosan (matrix) i.e., biocompatible, and biodegradable polymer, nanohydroxyapatite (nHA), and zinc oxide nanoparticles (ZnO) (fillers). Chitosan's properties make it suitable for wound healing applications, with antibacterial, analgesic, and hemostatic qualities. Bioactive glasses and nHA promote soft tissue regeneration and are known to expedite skin regeneration by encouraging angiogenesis and collagen deposition during the wound healing process. ZnO nanoparticles provide antibacterial properties and can enhance corrosion resistance. The incorporation of these materials into the coating aims to create a surface that is biocompatible, antibacterial, and conducive to wound healing. It must have good or improved corrosion resistance. This coating process has the potential to reduce the risk of tissue irritation, inflammation, and infections while promoting faster and more efficient healing. Therefor the composite was prepared and was coated through Electrophoretic deposition Method on SSPs. The treated / coated SSPs were then evaluated and compared, with non-treated / uncoated SSPS acting as the control. The corrosion resistance samples were carried out using Hank’s solution having pH of approximately 6.8. The corrosion resistance properties were improved having the lower values of Icorr of the treated SSPs with Ch /nHA /ZnO Composite films as compared to the untreated and SSPs. The antibacterial activity of these samples was also observed against bacterial strains of Escherichia coli and Staphylococcus aureus. In vitro antibacterial tests of these coated SSPs were carried out. The Ch/ nHA /ZnO coated SSPs showed promising antibacterial activity. Through this study, it was found that the Surgical Staple Pins coated with Ch /nHA /ZnO Composite films have improved corrosion resistance and antibacterial properties, and they have the potential to be used for wound healing.

Surgical Staple Pins (SSPs) play a significant role during the wound healing of surgical site infection in the medical world. This project focuses on enhancing the biocompatibility and performance of surgical staples through the synthesis of a specialized coating. Surgical staples are widely used in various medical procedures for wound closure and tissue approximation, offering advantages such as speed, consistency, minimal tissue reaction, and reduced scarring. However, to further improve their effectiveness, we aimed to develop a coating with specific properties. The selected materials for the coating include chitosan (matrix) i.e., biocompatible, and biodegradable polymer, nanohydroxyapatite (nHA), and zinc oxide nanoparticles (ZnO) (fillers). Chitosan's properties make it suitable for wound healing applications, with antibacterial, analgesic, and hemostatic qualities. Bioactive glasses and nHA promote soft tissue regeneration and are known to expedite skin regeneration by encouraging angiogenesis and collagen deposition during the wound healing process. ZnO nanoparticles provide antibacterial properties and can enhance corrosion resistance. The incorporation of these materials into the coating aims to create a surface that is biocompatible, antibacterial, and conducive to wound healing. It must have good or improved corrosion resistance. This coating process has the potential to reduce the risk of tissue irritation, inflammation, and infections while promoting faster and more efficient healing. Therefor the composite was prepared and was coated through Electrophoretic deposition Method on SSPs. The treated / coated SSPs were then evaluated and compared, with non-treated / uncoated SSPS acting as the control. The corrosion resistance samples were carried out using Hank’s solution having pH of approximately 6.8. The corrosion resistance properties were improved having the lower values of Icorr of the treated SSPs with Ch /nHA /ZnO Composite films as compared to the untreated and SSPs. The antibacterial activity of these samples was also observed against bacterial strains of Escherichia coli and Staphylococcus aureus. In vitro antibacterial tests of these coated SSPs were carried out. The Ch/ nHA /ZnO coated SSPs showed promising antibacterial activity. Through this study, it was found that the Surgical Staple Pins coated with Ch /nHA /ZnO Composite films have improved corrosion resistance and antibacterial properties, and they have the potential to be used for wound healing.