Fabrication Of Nanofiltration Membrane PES-Chitosan Incorporated With Drug-Based Emulsion For High Antifouling and Flux Property

Abstract

Growth in global population is causing a significant shortage of safe and clean drinking water, prompting the search for practical and cost-effective alternatives. Membrane filtration has demonstrated a lot of promises for the purpose of purifying water, but it confronts the difficulty of fouling, which reduces its lifetime. Currently, membrane technology is successfully used to treat water and is gaining popularity as a substitute for traditional methods of treating both water and wastewater. The membrane permeate flow directly affects these issues with the capital and operating expenses of membrane systems. Additionally, there are several ways to reduce fouling. Membrane-based water purification systems are most highly rated in pharmaceuticals, biotechnology, food industry, especially in the general water purification industry. Current study's objective is to create nanofiltration polyether sulfone membranes utilizing the phase inversion approach by combining chitosan and carbon nanotubes in an unique way to improve salt rejection. PES membrane containing chitosan, were created (0.75 wt. percent). To obtain antifouling capability, the goal is to successfully encapsulate a therapeutic drug. Considering the emulsion that is drug loaded and containdrug polycaprolactone (PCL) with cefotaxime was created utilizing nanotechnology,nano-precipitation method through the optimization of several process variables. The dip-coating of Chitosan membrane is done with the prepared PCL polycaprolactone With Polyvinyl alcohol surfactant. Further examinations of the coated membranes included functional group analyses with attenuated total (ATR-FTIR), morphology and cross-sectional views with (SEM), water retention for water uptake analysis, mechanical testing for membrane strength, roughness, flux and contact angle for water wettability. Two of the strains are used that are bacterial i-e E. coli, Gram-negative and Gram-positive S. aureus showed antifouling activity. The outcome of the studies show promising antifouling activity and provide the chance to treat water to get rid of contaminants and raise the standard of drinking water.