Abstract:
The discipline of medicinal chemistry has seen significant progress in the creation of drug
development plans targeted at enhancing the pharmacokinetic profiles, safety, and effectiveness of
currently available pharmaceuticals. This research work investigates the new strategy of
functionalizing commonly used medicines by linking N-protected amino acids, which increases
the medicines potential for therapeutic effects. N-protected amino acid moieties are selectively
added to therapeutic scaffolds using this technology, which makes it easier to create novel hybrid
compounds with increased pharmacological activity. As time went on, the value of medicine
increased, and new medications were created. Antibiotic-resistant illnesses have caused significant
strain on our healthcare system in the interim. The class of chemical compounds that has attracted
the most attention in this regard is amides. In our studies, we synthesized different amide
derivatives by condensation of N-protected amino acid with different aromatic amines in 1:1 M
concentration comprising of twelve novel compounds that have been synthesized. These
compounds were tested for their biological activities including anti-Cancer, and anti-Bacterial. SS 3, SS4, SS5, SS6, SS7, and SS8 are potent anti-Bacterial. These compounds have a high proportion
of healthy cell survival, and 40% cytotoxicity according to anticancer studies. These Amides are
described by using spectroscopic techniques, for example, FTIR, and NMR spectroscopy
