Functionalization of Commercial Drugs through N-Protected Amino Acid

Abstract

The discipline of medicinal chemistry has seen significant progress in the creation of drug development plans targeted at enhancing the pharmacokinetic profiles, safety, and effectiveness of currently available pharmaceuticals. This research work investigates the new strategy of functionalizing commonly used medicines by linking N-protected amino acids, which increases the medicines potential for therapeutic effects. N-protected amino acid moieties are selectively added to therapeutic scaffolds using this technology, which makes it easier to create novel hybrid compounds with increased pharmacological activity. As time went on, the value of medicine increased, and new medications were created. Antibiotic-resistant illnesses have caused significant strain on our healthcare system in the interim. The class of chemical compounds that has attracted the most attention in this regard is amides. In our studies, we synthesized different amide derivatives by condensation of N-protected amino acid with different aromatic amines in 1:1 M concentration comprising of twelve novel compounds that have been synthesized. These compounds were tested for their biological activities including anti-Cancer, and anti-Bacterial. SS 3, SS4, SS5, SS6, SS7, and SS8 are potent anti-Bacterial. These compounds have a high proportion of healthy cell survival, and 40% cytotoxicity according to anticancer studies. These Amides are described by using spectroscopic techniques, for example, FTIR, and NMR spectroscopy